TXA in Trauma Patients

Tranexamic acid (TXA) is an antifibrinolytic drug that can be used to reduce bleeding and the risk of death in trauma patients: 

• How it works
  TXA reduces blood loss by preventing the breakdown of fibrin, which helps stabilize blood as it clots.

• When to use it
  TXA is most effective when given within the first hour after injury but should be given within 3 hours. If given after 3 hours, there is a higher risk of death from bleeding. 


• Who to use it for
  TXA should be given to all trauma patients who are at risk of bleeding-related death, including those who need a blood transfusion. It's safe to administer to a wide range of patients and shouldn't be restricted to the most severely injured. 


• How to administer it
  A typical dose is 2g of TXA given slow bolus, 


• Benefits
  TXA has been shown to reduce mortality in trauma patients and can also reduce the need for blood transfusions. 


• Safety
  TXA is generally considered safe, with no serious side effects. 




• Pre-hospital administration of TXA is becoming more common and can be given by trained emergency personnel prehospital.

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